{"id":5601,"date":"2013-09-06T15:37:26","date_gmt":"2013-09-06T07:37:26","guid":{"rendered":"https:\/\/2blog.ilc.edu.tw\/3154\/2013\/09\/06\/%e4%bb%a5%e5%b6%84%e6%96%b0%e7%9a%84%e7%b6%a0%e8%89%b2%e5%8c%96%e5%ad%b8%e6%96%b9%e6%b3%95%e8%a3%bd%e9%80%a0%e6%8a%97%e7%99%8c%e8%97%a5%e7%89%a9%ef%bc%8d%e7%b4%ab%e6%9d%89%e9%86%87-taxol\/"},"modified":"2021-03-18T19:36:21","modified_gmt":"2021-03-18T11:36:21","slug":"%e4%bb%a5%e5%b6%84%e6%96%b0%e7%9a%84%e7%b6%a0%e8%89%b2%e5%8c%96%e5%ad%b8%e6%96%b9%e6%b3%95%e8%a3%bd%e9%80%a0%e6%8a%97%e7%99%8c%e8%97%a5%e7%89%a9%ef%bc%8d%e7%b4%ab%e6%9d%89%e9%86%87-taxol","status":"publish","type":"post","link":"https:\/\/2blog.ilc.edu.tw\/3154\/2013\/09\/06\/%e4%bb%a5%e5%b6%84%e6%96%b0%e7%9a%84%e7%b6%a0%e8%89%b2%e5%8c%96%e5%ad%b8%e6%96%b9%e6%b3%95%e8%a3%bd%e9%80%a0%e6%8a%97%e7%99%8c%e8%97%a5%e7%89%a9%ef%bc%8d%e7%b4%ab%e6%9d%89%e9%86%87-taxol\/","title":{"rendered":"\u4ee5\u5d84\u65b0\u7684\u7da0\u8272\u5316\u5b78\u65b9\u6cd5\u88fd\u9020\u6297\u764c\u85e5\u7269\uff0d\u7d2b\u6749\u9187 (Taxol)"},"content":{"rendered":"

ScienceDaily (Apr. 4, 2009) \u2014 \u592a\u5e73\u6d0b\u7d2b\u6749\u9019\u7a2e\u690d\u7269\u4e2d\u53ef\u4ee5\u63d0\u7149\u51fa\u4e00\u7a2e\u540d\u70ba\u7d2b\u6749\u9187 paclitaxel\uff08Taxol\uff09<\/span><\/a>\u7684\u6297\u764c\u85e5\u7269\uff0c\u7531\u65bc\u9019\u500b\u85e5\u7269\u7684\u7d50\u69cb\u8907\u96dc\uff0c\u751f\u7522\u56f0\u96e3\uff0c\u56e0\u6b64\u88fd\u9020\u6210\u672c\u4e00\u76f4\u5c45\u9ad8\u4e0d\u4e0b\u3002\u73fe\u5728\uff0c\u4f86\u81ea\u7f8e\u570b\u5bc6\u897f\u6839\u5dde\u7acb\u5927\u5b78\u7684\u751f\u5316\u5b78\u5bb6 Kevin Walker \u63d0\u4f9b\u4e86\u4e00\u7a2e\u517c\u5177\u6f5b\u529b\u8207\u6548\u7387\u4f86\u88fd\u9020\u9019\u500b\u6297\u764c\u85e5\u7269\u7684\u5d84\u65b0\u65b9\u6cd5\u3002<\/p>\n

\u57161. Shown is the broad specificity of the enzyme from yew plants that make the potent cancer drug paclitaxel (Taxol). Each acyl CoA shown can ‘funnel’ to the reactive site ‘conveyor’ of the enzyme and transfer to a prodrug skeleton.<\/p>\n

\u7d2b\u6749\u9187\u7b2c\u4e00\u6b21\u88ab\u5206\u96e2\u51fa\u4f86\u662f\u5728 1967 \u5e74\uff0c\u7576\u6642\u79d1\u5b78\u5bb6\u5011\u5728\u4e00\u7a2e\u540d\u70ba\u300c<\/span>\u592a\u5e73\u6d0b\u7d2b\u6749\uff08the Pacific yew\uff09<\/span><\/a>\u300d\u7684\u6a39\u76ae\u4e2d\u767c\u73fe\u9019\u7a2e\u6210\u5206<\/span>\uff0c\u800c\u8981\u88fd\u9020 paclitaxel \u57fa\u672c\u4e0a\u6709\u5169\u7a2e\u65b9\u6cd5\uff1a\u7b2c\u4e00\u7a2e\u662f\u5f97\u5230\u690d\u7269\u7684\u8403\u53d6\u7269\u8cea\u5f8c\uff0c\u4ee5\u5408\u6210\u7684\u624b\u6bb5\u9032\u884c\u7d50\u69cb\u7684\u4fee\u98fe\uff0c\u5229\u7528\u9019\u500b\u65b9\u6cd5\u6703\u4f7f\u7528\u5230\u6709\u6bd2\u7684\u6eb6\u5291\uff1b\u7b2c\u4e8c\u7a2e\u5247\u662f\u5229\u7528\u7d30\u80de\u57f9\u990a\u3001\u767c\u9175\u88fd\u5099<\/span>\u3002<\/p>\n

\u57162. \u592a\u5e73\u6d0b\u7d2b\u6749\u3002\uff08\u5716\u7247\u4f86\u6e90\uff1ahttp:\/\/www.southcotswoldramblers.org.uk\/051027uley10.jpg<\/span><\/a>\uff09<\/p>\n

\u57163. \u592a\u5e73\u6d0b\u7d2b\u6749\u8fd1\u62cd\u3002\uff08\u5716\u7247\u4f86\u6e90\uff1ahttp:\/\/arnica.csustan.edu\/boty3050\/medicinal\/taxus_brevifolia.jpg<\/span><\/a>\uff09<\/p>\n

\u57164. \u592a\u5e73\u6d0b\u7d2b\u6749\u6a39\u76ae\u3002\uff08\u5716\u7247\u4f86\u6e90\uff1ahttp:\/\/www.phcog.org\/Taxus\/BigYewBark.jpg<\/span><\/a>\uff09<\/p>\n

\u57165. \u88fd\u9020\u6297\u764c\u85e5\u7269\u7d2b\u6749\u9187\u7684\u50b3\u7d71\u6d41\u7a0b\u3002\uff08\u5716\u7247\u4f86\u6e90\uff1ahttp:\/\/www.novasep.com\/img\/synthesis\/high-potent-cytotoxic.gif<\/span><\/a>\uff09<\/p>\n

\u800c Walker \u4f7f\u7528\u7684\u65b9\u6cd5\u5247\u662f\u4ee5\u5929\u7136\u7684\u9175\u7d20\u4f86\u53d6\u4ee3\u4e0a\u8ff0\u7684\u5169\u7a2e\u65b9\u6cd5\u3002\u300c\u85e5\u5ee0\u5e0c\u671b\u80fd\u5728\u88fd\u9020 Taxol \u7684\u904e\u7a0b\u7576\u4e2d\u6e1b\u5c11\u751f\u7522\u7684\u6b65\u9a5f\uff0c\u540c\u6642\u4e5f\u80fd\u6e1b\u5c11\u5316\u5b78\u526f\u7522\u7269\u7684\u7522\u751f\u3002\u300d\u4ed6\u9019\u6a23\u8aaa\u5230\u3002<\/p>\n

\u57166. \u7d2b\u6749\u9187\u85e5\u7269\u7d50\u69cb\u3002<\/p>\n

Walker\uff0c\u4ed6\u662f\u5316\u5b78\u3001\u751f\u7269\u5316\u5b78\u4ee5\u53ca\u5206\u5b50\u751f\u7269\u5b78\u7684\u52a9\u7406\u6559\u6388\uff0c\u4ed6\u5c08\u7814\u65bc\u5728 Taxus \u690d\u7269\uff08Taxus plants\uff09\u4e2d\u4ee5\u4e0d\u540c\u9175\u7d20\u7684\u7d44\u5408\u4f86\u88fd\u9020 Taxol \u5206\u5b50\u3002\u300c\u9019\u500b\u904e\u7a0b\u5c31\u50cf\u662f\u5229\u7528\u8abf\u8272\u76e4\u4f86\u8abf\u8272\uff0c\u6211\u5011\u53ef\u4ee5\u5f9e\u8abf\u8272\u76e4\u4e2d\u9078\u64c7\u4e0d\u540c\u7684\u984f\u8272\uff0c\u9019\u4e9b\u984f\u8272\u5c31\u50cf\u662f\u9078\u64c7\u4e0d\u540c\u7684\u9175\u7d20\u822c\uff0c\u56e0\u6b64\u5206\u5b50\u4fbf\u80fd\u4ee5\u5404\u7a2e\u8def\u5f91\u4f86\u7522\u751f\u3002\u9175\u7d20\u63a5\u624b\u4e86\u9019\u500b\u904e\u7a0b\u4e2d\u7684\u6240\u6709\u5de5\u4f5c\u3002\u300d<\/p>\n

\u57167. \u958b\u767c\u9175\u7d20\u7d44\u88dd\u88fd\u5099\u7d2b\u6749\u9187\u7684 Kevin Walker \u52a9\u7406\u6559\u6388\u3002\uff08\u5716\u7247\u4f86\u6e90\uff1ahttp:\/\/www.eurekalert.org\/multimedia\/pub\/13292.php?from=134259<\/span><\/a>\uff09<\/p>\n

Walker \u8aaa\u5230\uff1a\u300c\u8ddf\u50b3\u7d71\u7684\u5316\u5b78\u65b9\u6cd5\u6bd4\u8f03\u8d77\u4f86\uff0c\u690d\u7269\u9175\u7d20\u8d70\u4e00\u6b65\uff0c\u50b3\u7d71\u65b9\u6cd5\u53ef\u80fd\u8981\u8d70\u597d\u591a\u6b65<\/span>\u3002\u5728\u6211\u5011\u7684\u904e\u7a0b\u4e2d\uff0c\u6211\u5011\u5229\u7528\u5efa\u69cb\u7d2b\u6749\u9187\u7684\u65b9\u6cd5\u662f\u5229\u7528\u751f\u7269\u7d44\u88dd\u751f\u7522\u7dda\u7684\u6a21\u5f0f\u4f86\u9032\u884c\uff0c\u6bcf\u4e00\u500b\u9175\u7d20\u90fd\u626e\u6f14\u8457\u4ed6\u7684\u89d2\u8272\u4f86\u5275\u9020\u51fa\u6700\u7d42\u7684\u7522\u7269\u3002\u540c\u6642\u5728\u7d44\u88dd\u6574\u500b\u5206\u5b50\u7684\u904e\u7a0b\u4e2d\u53ea\u8981\u5c0e\u5165\u4e00\u4e9b\u7279\u6b8a\u7684\u9175\u7d20\u4fbf\u53ef\u4ee5\u4f7f\u6574\u500b\u7d50\u69cb\u7522\u751f\u4e9b\u5fae\u7684\u6539\u8b8a\uff0c\u5982\u6b64\u5c31\u53ef\u4ee5\u5275\u9020\u51fa\u5d84\u65b0\u7684\u7d2b\u6749\u9187\u5206\u5b50<\/span>\u3002\u9019\u63d0\u9ad8\u4e86\u627e\u5c0b\u85e5\u6548\u66f4\u4f73\u4e4b\u85e5\u7269\u7684\u6548\u7387\uff0c\u6700\u7d42\u4fbf\u662f\u5f97\u5230\u66f4\u597d\u7684\u5065\u5eb7\u6cbb\u7642\u3002\u300d<\/p>\n

\u57168. Walker \u6559\u6388\u6240\u5831\u5c0e\u4e4b\u4ee5\u9175\u7d20\u7d44\u5408\u6cd5\u5408\u6210\u7d2b\u6749\u9187\u7684\u65b9\u6cd5\u3002\uff08\u5716\u7247\u4f86\u6e90\uff1ahttp:\/\/pubs.acs.org\/doi\/abs\/10.1021\/ja900545m<\/span><\/a>\uff09<\/p>\n

\u7d2b\u6749\u9187\uff08Taxol\uff09\u662f\u76ee\u524d\u6cbb\u7642\u8a31\u591a\u7a2e\u764c\u75c7\u7684\u7b2c\u4e00\u7dda\u7528\u85e5\uff0c\u5305\u542b\u4e73\u764c\u3001\u80ba\u764c\u3001\u8166\u764c\u4ee5\u53ca\u9838\u764c\u7b49\u7b49<\/span>\uff0cBarbara Conley \u9019\u6a23\u8aaa\u5230\uff0c\u5979\u662f MSU Department of Medicine\u2019s<\/span><\/a> \u8840\u6db2\u5b78\u53ca\u816b\u7624\u5b78\u7684\u4e3b\u4efb\u3002<\/p>\n

\u57169. MSU Department of Medicine\u2019s \u8840\u6db2\u5b78\u53ca\u816b\u7624\u5b78\u7684\u4e3b\u4efb Barbara Conley\uff08\u5716\u7247\u4f86\u6e90\uff1ahttp:\/\/www.hemonc.msu.edu\/Graphics\/Conley.jpg<\/span><\/a>\uff09<\/p>\n

\u571610. \u91ab\u7528\u7d2b\u6749\u9187\u5305\u88dd\u3002\uff08\u5716\u7247\u4f86\u6e90\uff1ahttp:\/\/www.parentarx.com\/files\/prodimages\/paclitaxel_mid.jpg<\/span><\/a>\uff09<\/p>\n

\u6839\u64da Global Industry Analysts Inc.<\/span><\/a> \u8abf\u67e5\u986f\u793a\uff1a\u5149\u662f 1997 \u5e74\uff0c\u7d2b\u6749\u9187\u6240\u5275\u9020\u51fa\u4f86\u7684\u5e02\u5834\u6536\u76ca\u4fbf\u5df2\u7d93\u9ad8\u9054 1.95 \u5104\u7f8e\u91d1\uff0c\u800c\u4e14\u5230\u4e86 2012 \u5e74\uff0c\u5c0d\u65bc\u6f5b\u5728\u7684\u5d84\u65b0\u7528\u9014\uff0c\u5982\u8001\u4eba\u7661\u5446\u75c7\u4ee5\u53ca\u80ba\u7d50\u6838\u7b49\uff0c\u9084\u53ef\u4ee5\u63a8\u52d5\u5168\u4e16\u754c\u5e02\u5834\u92b7\u552e\u7d04 10 \u500b\u767e\u5206\u9ede\u3002<\/p>\n

Walker \u7814\u7a76\u5718\u968a\u76ee\u524d\u662f\u7531 Michigan Agricultural Experiment Station \u63d0\u4f9b\u8d0a\u52a9\u3002MAES \u4e3b\u4efb Steve Pueppke<\/span><\/a> \u8aaa\u5230\uff1a\u300c\u5c0d\u65bc\u8207\u4eba\u985e\u91ab\u85e5\u53ca\u5176\u4ed6\u5065\u5eb7\u7167\u8b77\u7522\u54c1\u6709\u8457\u8d8a\u4f86\u8d8a\u5bc6\u4e0d\u53ef\u5206\u7684\u690d\u7269\u8207\u5929\u7136\u7269\u7cfb\u7d71\u7684\u79d1\u5b78\u53ca\u6280\u8853\u800c\u8a00\uff0c\u79d1\u5b78\u5bb6\u5011\u4e5f\u5c31\u6703\u8d8a\u6ce8\u91cd\u65bc\u627e\u5c0b\u66f4\u6709\u6548\u7387\u540c\u6642\u517c\u5099\u66f4\u74b0\u4fdd\u7684\u85e5\u7269\u88fd\u9020\u65b9\u6cd5\u3002\u800c\u91dd\u5c0d\u4eba\u985e\u8207\u52d5\u7269\u5065\u5eb7\u7684\u7814\u7a76\u6539\u9032\u4f86\u8aaa\uff0c\u5247\u662f MAES \u4f7f\u547d\u4e2d\u7684\u4e00\u500b\u5ee3\u5927\u4e14\u91cd\u8981\u7684\u90e8\u5206\u3002\u300d<\/p>\n

\u571611. MAES \u4e3b\u4efb Steve Pueppke\uff08\u5716\u7247\u4f86\u6e90\uff1ahttp:\/\/www.maes.msu.edu\/about\/pueppke.htm<\/span><\/a>\uff09<\/p>\n

\u5728 Walker \u6559\u6388\u7814\u7a76\u5718\u968a\u4e2d\u9084\u5305\u542b\u6709\u7814\u7a76\u751f Danielle Nevarez\u3001Yemane Mengistu \u53ca Irosha Nawarathne \u7b49\u4eba\u3002\u4ed6\u5011\u7684\u767c\u73fe\u5df2\u767c\u8868\u5728\u77e5\u540d\u7684\u7f8e\u570b\u5316\u5b78\u5354\u6703\u671f\u520a\uff08Journal of the American Chemical Society\uff09\u7576\u4e2d\u3002<\/p>\n

\u00a0
\u539f\u59cb\u6587\u737b\uff1a
Danielle M. Nevarez, Yemane A. Mengistu, Irosha N. Nawarathne and Kevin D. Walker.
An N-Aroyltransferase of the BAHD Superfamily Has Broad Aroyl CoA Specificity in Vitro with Analogues of N-Dearoylpaclitaxel.
Journal of the American Chemical Society, 2009; 090402100406033 DOI: 10.1021\/ja900545m
http:\/\/pubs.acs.org\/doi\/abs\/10.1021\/ja900545m<\/span><\/a><\/p>\n

Adapted from materials provided by Michigan State University.<\/p>\n

\u539f\u59cb\u5831\u5c0e\uff1a
ScienceDaily\uff1a‘Green Chemistry’ Could Ease Manufacture, Boost Usefulness Of Cancer Drug<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

ScienceDaily (Apr. 4, 2009) \u2014 \u592a\u5e73\u6d0b\u7d2b\u6749\u9019\u7a2e\u690d\u7269\u4e2d\u53ef\u4ee5\u63d0\u7149\u51fa\u4e00\u7a2e\u540d\u70ba\u7d2b\u6749\u9187 pa … <\/p>\n

\u95b1\u8b80\u5168\u6587\u3008\u4ee5\u5d84\u65b0\u7684\u7da0\u8272\u5316\u5b78\u65b9\u6cd5\u88fd\u9020\u6297\u764c\u85e5\u7269\uff0d\u7d2b\u6749\u9187 (Taxol)\u3009<\/span><\/a><\/p>\n","protected":false},"author":1605,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-5601","post","type-post","status-publish","format-standard","hentry","category-uncategorized"],"meta_key":{"lt_post_id":["420792"]},"_links":{"self":[{"href":"https:\/\/2blog.ilc.edu.tw\/3154\/wp-json\/wp\/v2\/posts\/5601"}],"collection":[{"href":"https:\/\/2blog.ilc.edu.tw\/3154\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/2blog.ilc.edu.tw\/3154\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/2blog.ilc.edu.tw\/3154\/wp-json\/wp\/v2\/users\/1605"}],"replies":[{"embeddable":true,"href":"https:\/\/2blog.ilc.edu.tw\/3154\/wp-json\/wp\/v2\/comments?post=5601"}],"version-history":[{"count":1,"href":"https:\/\/2blog.ilc.edu.tw\/3154\/wp-json\/wp\/v2\/posts\/5601\/revisions"}],"predecessor-version":[{"id":6022,"href":"https:\/\/2blog.ilc.edu.tw\/3154\/wp-json\/wp\/v2\/posts\/5601\/revisions\/6022"}],"wp:attachment":[{"href":"https:\/\/2blog.ilc.edu.tw\/3154\/wp-json\/wp\/v2\/media?parent=5601"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/2blog.ilc.edu.tw\/3154\/wp-json\/wp\/v2\/categories?post=5601"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/2blog.ilc.edu.tw\/3154\/wp-json\/wp\/v2\/tags?post=5601"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}