{"id":4816,"date":"2015-03-28T21:37:30","date_gmt":"2015-03-28T13:37:30","guid":{"rendered":"https:\/\/2blog.ilc.edu.tw\/1909\/2015\/03\/28\/17%e5%80%8b%e6%94%b9%e8%ae%8a%e6%ad%b7%e5%8f%b2%e7%9a%84%e5%8c%96%e5%ad%b8%e6%95%85%e4%ba%8b-%e7%ac%ac10%e7%ab%a0%e9%98%bf%e6%96%af%e5%8c%b9%e9%9d%88%e8%88%87%e6%8a%97%e7%94%9f%e7%b4%a0\/"},"modified":"2015-03-28T21:37:30","modified_gmt":"2015-03-28T13:37:30","slug":"17%e5%80%8b%e6%94%b9%e8%ae%8a%e6%ad%b7%e5%8f%b2%e7%9a%84%e5%8c%96%e5%ad%b8%e6%95%85%e4%ba%8b-%e7%ac%ac10%e7%ab%a0%e9%98%bf%e6%96%af%e5%8c%b9%e9%9d%88%e8%88%87%e6%8a%97%e7%94%9f%e7%b4%a0","status":"publish","type":"post","link":"https:\/\/2blog.ilc.edu.tw\/1909\/2015\/03\/28\/17%e5%80%8b%e6%94%b9%e8%ae%8a%e6%ad%b7%e5%8f%b2%e7%9a%84%e5%8c%96%e5%ad%b8%e6%95%85%e4%ba%8b-%e7%ac%ac10%e7%ab%a0%e9%98%bf%e6%96%af%e5%8c%b9%e9%9d%88%e8%88%87%e6%8a%97%e7%94%9f%e7%b4%a0\/","title":{"rendered":"17\u500b\u6539\u8b8a\u6b77\u53f2\u7684\u5316\u5b78\u6545\u4e8b-\u7b2c10\u7ae0\u963f\u65af\u5339\u9748\u8207\u6297\u751f\u7d20"},"content":{"rendered":"

\u5fb7\u570b\u8207\u745e\u58eb\u5728\u67d3\u6599\u5de5\u696d\u4e0a\u7684\u5927\u91cf\u6295\u8cc7\uff0c\u4fc3\u6210\u4e86\u4e8c\u5341\u4e16\u7d00\u521d\u671f\u5316\u5b78\u5de5\u696d\u7684\u7a81\u98db\u731b\u9032\uff0c<\/span><\/p>\n

\u800c\u5176\u4e2d\u6240\u5e36\u4f86\u7684\u7d93\u6fdf\u5229\u76ca\uff0c\u66f4\u6709\u52a9\u65bc\u5176\u4ed6\u5404\u500b\u5c64\u9762\u7684\u767c\u5c55\u3002<\/span><\/p>\n

\u6bd4\u65b9\u8aaa\u67d3\u6599\u5de5\u696d\u5e36\u52d5\u4e86\u5316\u5b78\u7684\u9032\u5c55\uff0c\u4eba\u5011\u958b\u59cb\u7814\u7a76\u91cf\u7522\u53cd\u61c9\u6240\u9700\u7684\u689d\u4ef6\uff0c<\/span><\/p>\n

\u4e26\u63a8\u51fa\u6709\u5229\u65bc\u5f8c\u8d77\u7684\u88fd\u85e5\u5de5\u696d\u6240\u9700\u7684\u7d14\u5316\u8207\u5206\u96e2\u6280\u8853\u3002<\/span><\/p>\n

\u5fb7\u570b\u62dc\u8033\u516c\u53f8\u662f\u6700\u65e9\u6d1e\u6089\u5316\u5b78\u88fd\u85e5\u5177\u6709\u9f90\u5927\u5546\u6a5f\u7684\u5148\u9a45\u4e4b\u4e00\uff0c<\/span><\/p>\n

\u5176\u4e2d\u6700\u6709\u8457\u540d\u7684\u4f8b\u5b50\uff0c\u5c31\u662f\u4eca\u65e5\u71b1\u92b7\u5168\u4e16\u754c\u7684\u963f\u65af\u5339\u9748\u3002<\/span><\/p>\n

1893\u5e74\uff0c\u62dc\u8033\u516c\u53f8\u7684\u5316\u5b78\u5bb6\u970d\u592b\u66fc\uff08Felix\u00a0 Hofmann\uff09\u958b\u59cb\u7814\u7a76\u6c34\u694a\u9178\u7684\u7279\u6027;<\/span><\/p>\n

\u9019\u7a2e\u5206\u5b50\u662f\u5f9e1827\u5e74\u81ea\u67f3\u6a39\u76ae\u4e2d\u6240\u767c\u73fe\u5177\u6709\u93ae\u75db\u6548\u679c\u7684\u6c34\u694a\u4e2d\u53d6\u5f97\u7684\u3002<\/span><\/p>\n

\u6c34\u694a\u7684\u4e3b\u8981\u6d3b\u6027\u6210\u5206\u70ba\u6c34\u694a\u9178\uff0c\u4e0d\u4f46\u53ef\u4ee5\u6d88\u71b1\u3001\u93ae\u75db\uff0c\u540c\u6642\u4e5f\u5177\u6709\u6291\u5236\u767c\u708e\u7684\u529f\u6548\u3002<\/span><\/p>\n

\u7d14\u5316\u7684\u6c34\u694a\u9178\u5206\u5b50\u6bd4\u5929\u7136\u7684\u6c34\u694a\u66f4\u5177\u7642\u6548\uff0c\u4e0d\u904e\u537b\u6703\u523a\u6fc0\u4eba\u9ad4\u7684\u8178\u80c3\u58c1\u3002<\/span><\/p>\n

\u970d\u592b\u66fc\u4e4b\u6240\u4ee5\u6703\u5c0d\u6c34\u694a\u9178\u5206\u5b50\u7522\u751f\u8208\u8da3\uff0c<\/span><\/p>\n

\u662f\u56e0\u70ba\u5b83\u80fd\u6e1b\u8f15\u985e\u98a8\u6fd5\u95dc\u7bc0\u708e\u70ba\u4ed6\u7236\u89aa\u6240\u5e36\u4f86\u5f97\u75bc\u75db\uff0c\u4f46\u5176\u6b62\u75db\u6548\u679c\u537b\u6703\u96a8\u8457\u6642\u9593\u905e\u6e1b\u3002<\/span><\/p>\n

\u6709\u9451\u65bc\u6b64\uff0c\u970d\u592b\u66fc\u5617\u8a66\u8b93\u4ed6\u7236\u89aa\u670d\u7528\u53e6\u4e00\u7a2e\u5f9e\u6c34\u694a\u9178\u884d\u751f\u800c\u4f86\u7684\u5316\u5b78\u5206\u5b50-\u4e59\u91af\u6c34\u694a\u9178\u3002<\/span><\/p>\n

\u9019\u500b\u5177\u6709\u4e59\u91af\u57fa\u7684\u6c34\u694a\u9178\u96a8\u5f8c\u88ab\u8b49\u5be6\u5177\u6709\u9ad8\u5ea6\u7684\u7642\u6548\uff0c\u800c\u4e14\u5c0d\u4eba\u9ad4\u4e5f\u8f03\u6eab\u548c\u3002<\/span><\/p>\n

1899\u5e74\uff0c\u62dc\u8033\u516c\u53f8\u958b\u59cb\u8ca9\u552e\u5c0f\u5305\u88dd\u7684\u963f\u65af\u5339\u9748\u85e5\u7c89\u3002<\/span><\/p>\n

\u6211\u5011\u73fe\u5728\u719f\u77e5\u7684\u300caspirin\u300d \u963f\u65af\u5339\u9748<\/strong>\uff0c\u9019\u500b\u5b57\uff0c<\/span><\/p>\n

\u5c31\u662f\u7d50\u5408\u4e86acetyl(\u4e59\u91af)\u4e2d\u7684’a’\uff0c\u4ee5\u53caSpiraea ulmaria(\u7e61\u7dda\u6a58\u690d\u7269)\u4e2d\u7684’spir’\u3002<\/span><\/p>\n

\u6b64\u5f8c\uff0c\u62dc\u8033\u516c\u53f8\u5e7e\u4e4e\u7b49\u65bc\u963f\u65af\u5339\u9748\u7684\u4ee3\u540d\u8a5e\u3002<\/span><\/p>\n

 <\/p>\n

\u78fa\u80fa(Sulfa drug)\u50b3\u5947<\/strong><\/span><\/p>\n

\u7576\u970d\u592b\u66fc\u9032\u884c\u963f\u65af\u5339\u9748\u7814\u7a76\u6642\uff0c<\/span><\/p>\n

\u5fb7\u570b\u91ab\u5e2b\u827e\u5229\u5e0c\uff08Paul Echrlich\uff09\uff081908\u5e74\u8afe\u8c9d\u723e\u91ab\u5b78\u734e\u5f97\u4e3b\uff09<\/span><\/p>\n

\u7814\u7a76\u5229\u7528\u6709\u6bd2\u7684\u67d3\u6599\u5206\u5b50\u4f86\u6d88\u6ec5\u906d\u5230\u611f\u67d3\u7684\u7279\u5b9a\u7d44\u7e54\uff0c\u800c\u4e0d\u81f3\u65bc\u50b7\u5bb3\u5230\u6574\u500b\u4eba\u9ad4\u3002<\/span><\/p>\n

\u827e\u5229\u5e0c\u5c07\u9019\u500b\u60f3\u6cd5\u7a31\u70ba\u300c\u795e\u5947\u5b50\u5f48\u300d\uff08magic bullet\uff09~\u9019\u9846\u7531\u6bd2\u6027\u7684\u67d3\u6599\u5206\u5b50\u6240\u69cb\u6210\u7684\u5b50\u5f48\uff0c<\/span><\/p>\n

\u53ef\u4ee5\u7cbe\u6e96\u5730\u7784\u6e96\u76ee\u6a19\u7d44\u7e54\uff0c\u4e26\u5c07\u4e4b\u4e00\u8209\u7e96\u6ec5\u3002<\/span><\/p>\n

1909\u5e74\u827e\u5229\u5e0c\u7814\u7a76\u51fa\u4e00\u7a2e\u542b\u7837\u7684\u82b3\u9999\u65cf\u5206\u5b50\uff0c\u800c\u4e14\u8b49\u5be6\u80fd\u6709\u6548\u5730\u6d88\u6ec5\u6885\u6bd2\u87ba\u65cb\u9ad4\u3002<\/span><\/p>\n

\u8207\u827e\u5229\u5e0c\u5408\u4f5c\u7684Hoechst\u516c\u53f8\u5c07\u9019\u9805\u65b0\u7522\u54c1\u547d\u540d\u70ba\u300e\u6492\u723e\u4f5b\u6563\u300f\uff08salvarsan\uff09\uff0c\u4e26\u65bc1910\u5e74\u4e0a\u5e02\u3002<\/span><\/p>\n

\u5230\u4e861930\u5e74\u4ee3\uff0c<\/span><\/p>\n

\u53d7\u96c7\u65bc\u5fb7\u570bIG Farben\u96c6\u5718\u7684\u675c\u99ac\u514b\u4f7f\u7528\u4e00\u7a2e\u7a31\u70ba\u300c\u767e\u6d6a\u591a\u606f\u300d\uff08prontosil red\uff09\u7684\u67d3\u5291\uff0c<\/span><\/p>\n

\u9019\u7a2e\u85e5\u5291\u80fd\u6291\u5236\u93c8\u7403\u83cc\u7e41\u6b96\u7684\u5947\u6548\uff0c<\/span><\/p>\n

\u5f8c\u4f86\u8b49\u5be6\u9019\u500b\u85e5\u5291\u7684\u6bba\u83cc\u6548\u679c\u662f\u5728\u4eba\u9ad4\u5167\u80fd\u88c2\u89e3\u6210\u5177\u6709\u6bba\u83cc\u6548\u679c\u7684\u80fa\u82ef\u78fa\u80fa\uff08sulfanilamide \uff09\u3002<\/span><\/p>\n

\u80fa\u82ef\u78fa\u80fa\u985e\u7684\u5206\u5b50\u5927\u5c0f\u548c\u5f62\u72c0\u53ef\u4ee5\u963b\u65b7\u7d30\u83cc\u7e41\u6b96\u6642\u6240\u9700\u7684\u8449\u9178\u76f8\u4f3c\uff0c<\/span><\/p>\n

\u9019\u4e5f\u662f\u6297\u751f\u7d20\u5f97\u4ee5\u6291\u5236\u7d30\u83cc\u611f\u67d3\u7684\u539f\u56e0\u3002<\/span><\/p>\n

\u7d30\u83cc\u9ad4\u5167\u8ca0\u8cac\u5408\u6210\u8449\u9178\u7684\u9175\u7d20\uff0c\u5c0d\u65bc\u5c0d\u80fa\u57fa\u82ef\u7532\u9178\uff0c\u548c\u5341\u5206\u76f8\u4f3c\u7684\u80fa\u82ef\u78fa\u80fa\u985e\u5206\u5b50\uff0c\u4f3c\u4e4e\u6c92\u6709\u9451\u5225\u80fd\u529b\u3002<\/span><\/p>\n

\u56e0\u6b64\uff0c\u7d30\u83cc\u9ad4\u5167\u7684\u9175\u7d20\u932f\u7528\u76ee\u6a19\u4f86\u88fd\u9020\u8449\u9178\uff0c\u7d42\u56e0\u8449\u9178\u4e0d\u8db3\u800c\u6b7b\u4ea1\u3002<\/span><\/p>\n

 <\/p>\n

\u76e4\u5c3c\u897f\u6797Penicillium<\/strong><\/span><\/p>\n

\u00a0\u00a0\u00a0\u00a0\u00a0 \u6700\u65e9\u958b\u59cb\u4f7f\u7528\u7684\u6297\u751f\u7d20\u662f\u76e4\u5c3c\u897f\u6797\uff0c\u800c\u4e14\u6cbf\u7528\u81f3\u4eca\u3002<\/span><\/p>\n

1877\u5e74\uff0c\u5df4\u65af\u5fb7\u9996\u5148\u63d0\u51fa\u300e\u5229\u7528\u5fae\u751f\u7269\u4f86\u6d88\u6ec5\u4ed6\u7a2e\u5fae\u751f\u7269\u300f\u7684\u89c0\u9ede\u3002<\/span><\/p>\n

\u4ed6\u5229\u7528\u5be6\u9a57\u8b49\u660e\uff0c\u5982\u679c\u5728\u5c3f\u6db2\u4e2d\u52a0\u5165\u666e\u901a\u7684\u7d30\u83cc\uff0c\u53ef\u4ee5\u6291\u5236\u5c3f\u6db2\u4e2d\u4e00\u7a2e\u70ad\u75bd\u83cc\u7684\u751f\u9577\u3002<\/span><\/p>\n

\u96a8\u5f8c\uff0c\u674e\u65af\u7279\u91ab\u751f\u4e5f\u5411\u91ab\u5b78\u754c\u8b49\u660e\u4e86\u915a\u7684\u6bba\u83cc\u6d88\u6bd2\u80fd\u529b\uff0c\u4e26\u5c0d\u9ef4\u83cc\u7684\u7279\u6027\u9032\u884c\u7814\u7a76\u3002<\/span><\/p>\n

\u4ed6\u66fe\u7d93\u5229\u7528\u9752\u9ef4\u83cc\u5c6c\uff08Penicillium\uff09\u7684\u8403\u53d6\u6db2\uff0c\u6210\u529f\u6cbb\u7642\u4e86\u4e00\u540d\u98fd\u53d7\u6f70\u7621\u6240\u82e6\u7684\u75c5\u60a3\u3002<\/span><\/p>\n

\u00a0\u00a0\u00a0\u00a0\u00a0 1928\u5e74\uff0c\u82f1\u570b\u502b\u6566\u8056\u746a\u9e97\u91ab\u9662\u7684\u5167\u79d1\u91ab\u5e2b\u5f17\u840a\u660e\uff08Alexander Fleming\uff09\u767c\u73fe\uff0c<\/span><\/p>\n

\u4ed6\u6b63\u5728\u7814\u7a76\u7684\u8461\u8404\u7403\u83cc\u57f9\u990a\u6db2\u88ab\u4e00\u7a2e\u9752\u9ef4\u83cc\u6c61\u67d3\uff0c\u4e26\u6ce8\u610f\u5230\u9ef4\u83cc\u83cc\u843d\u6703\u9010\u6f38\u8b8a\u5f97\u900f\u660e\u7d42\u81f3\u74e6\u89e3\u3002<\/span><\/p>\n

\u5728\u597d\u5947\u5fc3\u7684\u9a45\u4f7f\u4e0b\uff0c\u5f17\u840a\u660e\u505a\u4e86\u9032\u4e00\u6b65\u7684\u5be6\u9a57<\/span>\uff0c<\/span><\/p>\n

\u4ed6\u63a8\u6e2c\u57f9\u990a\u6db2\u4e2d\u7684\u9ef4\u83cc\uff0c\u80fd\u5206\u6ccc\u6291\u5236\u8461\u8404\u7403\u83cc\u751f\u9577\u7684\u7269\u8cea\uff0c\u7a0d\u5f8c\u4e5f\u4ee5\u5be6\u9a57\u8b49\u660e\u4e86\u81ea\u5df1\u7684\u60f3\u6cd5\u3002<\/span><\/p>\n

\u7531\u65bc\u7576\u6642\u4ecd\u4ee5\u78fa\u80fa\u5291\u70ba\u6cbb\u7642\u7d30\u83cc\u611f\u67d3\u7684\u4e3b\u8981\u65b9\u6cd5\uff0c\u56e0\u6b64\u76e4\u5c3c\u897f\u6797\u7684\u81e8\u5e8a\u6e2c\u8a66\u88ab\u64f1\u7f6e\u3002<\/span><\/p>\n

\u5230\u4e861946\u5e74\uff0c\u76e4\u5c3c\u897f\u6797\u7d50\u69cb\u7684\u8b0e\u5718\u7d42\u65bc\u88ab\u89e3\u958b\u4e86\uff0c<\/span><\/p>\n

\u4e0d\u904e\u7b2c\u4e00\u6279\u5408\u6210\u7684\u76e4\u5c3c\u897f\u6797\u554f\u4e16\uff0c\u537b\u662f1957\u5e74\u7684\u4e8b\u4e86\u3002<\/span><\/p>\n

\u76e4\u5c3c\u897f\u6797\u7684\u5316\u5b78\u7d50\u69cb\u5176\u5be6\u4e26\u4e0d\u8907\u96dc\uff0c<\/span><\/p>\n

\u5b83\u5177\u6709\u4e00\u500b\u7a31\u70babeta\u5167\u91af\u80fa\u7684\u7f55\u898b\u56db\u74b0\u7d20\u7d50\u69cb\uff0c\u662f\u7531\u56db\u500b\u76f8\u7570\u539f\u5b50\u6240\u7d44\u6210\u7684\u3002<\/span><\/p>\n

\u4e00\u822c\u7d30\u83cc\u90fd\u6709\u7d30\u80de\u58c1\uff0c\u4e5f\u90fd\u5177\u6709\u80fd\u5408\u6210\u7d30\u80de\u58c1\u7684\u9175\u7d20\u3002<\/span><\/p>\n

\u9019\u7a2e\u9175\u7d20\u4e5f\u6703\u4f5c\u7528\u5728beta\u5167\u91af\u80fa\u74b0\u5167\uff0c\u4f7f\u76e4\u5c3c\u897f\u6797\u4e2d\u7684\u74b0\u72c0\u7d50\u69cb\u6253\u958b\u800c\u91cb\u653e\u51fa\u74b0\u72c0\u5f35\u529b\u3002<\/span><\/p>\n

\u7576\u9019\u500b\u53cd\u61c9\u767c\u751f\u6642\uff0c<\/span><\/p>\n

\u7d30\u83cc\u9175\u7d20\u4e0a\u7684OH\u57fa\u4fbf\u6703\u7522\u751f\u91af\u5316\u4f5c\u7528(acylation\uff0c\u8207\u6c34\u694a\u9178\u8f49\u5316\u6210\u963f\u65af\u5339\u9748\u7684\u53cd\u61c9\u76f8\u540c)\u7576\u9019\u500b\u53cd\u61c9\u767c\u751f\u6642\uff0c<\/span><\/p>\n

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\u76e4\u5c3c\u897f\u6797\u7684\u4e94\u539f\u5b50\u74b0\u72c0\u7d50\u69cb\u4ecd\u7136\u4fdd\u6301\u4e0d\u8b8a\uff0c\u4e0d\u904e\u539f\u672c\u7684\u56db\u54e1\u74b0\u7d50\u69cb\u537b\u5df2\u7d93\u6253\u958b\u4e86\u3002<\/span><\/p>\n

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